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Yes, but under strict conditions

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(7/13/2018) If Sower of Discord's controller is dealt damage that causes them to lose the game at the same time that either of the chosen players is dealt damage, Sower of Discord's triggered ability won't resolve and the other chosen player won't lose life.

The point is just to have a good time, and find what gives you the most from your gaming experience.

Using a Toploader makes this less of an issue